Micky van de Ven Double Ends Everton's Run at Brand New Home Ground
The Dutch defender emerged as the initial defender to score twice in a English top-flight game for Spurs since Jan Vertonghen in March 2013.
At a glance
Micky Van de Ven heads into the net two times in first half
Everton's Jake O'Brien has goal ruled after video check
Senegalese midfielder nets third in dying moments
This loss is the Merseyside club's initial at their new ground
The Tottenham defender scored twice as Tottenham prolonged their unbeaten run on the road in the top division and delivered Everton their initial loss at their new home.
The Toffees were unbeaten in their five previous fixtures at their new ground at the dockside location, having left Goodison Park behind after 133 years at the end of the previous campaign.
But Tottenham's leader the Dutchman struck on two occasions from set-pieces in the opening 45 minutes to place their strong form at risk, and they were failed to mount a comeback before the midfielder - assisted by ex-Everton forward the Brazilian - headed home a third to put the game to bed.
The Everton defender thought he had levelled the tally a short while after the defender's opener, glancing a bullet header past Guglielmo Vicario from an Everton corner.
The Portuguese striker, in the meantime, failed to convert a handful of chances, while Vicario made a succession of fine saves to ensure Tottenham went five matches on the road unbeaten in the Premier League.
But the VAR stepped in, advising Craig Pawson to check the goal on the screen and the referee ruled that the winger and the attacker were in offside positions and had interfered with the Spurs keeper.
The win elevates Thomas Frank's team into third place in the division, a handful of points off north London rivals and table-toppers the Gunners.
The Merseyside club remain in 14th position and are six points clear of the relegation zone.
Tottenham analysis: The defender fulfils duties at each end of the field
Following a drab weekday performance in the European competition against the French side, where they mustered a mere attempts on goal, Frank chose Randal Kolo Muani up front instead of ex-Everton forward the Brazilian.
The summer signing was unable to make much of an impact before being substituted for the substitute after 60 minutes on the pitch, but it turns out he proved unnecessary in the end.
Defender the Dutchman transformed into an offensive threat to be feared.
Spurs' opening strike came from a cleverly executed set-piece play, with the midfielder directing the ball back across the face of goal for an unmarked the defender to head home.
And Ven de Ven - stepping up as captain in Cristian Romero's absence - added his second in added time as he outjumped the England keeper to nod in.
Van de Ven was just as impressive in defensive duties, combining effectively with his defensive colleague as the duo dealt superbly with the 34 crosses thrown their way by Everton.
Toffees breakdown: Toffees lacking finishing touch
The club's recent stadium had been a fortress, but it appears the novelty may have worn off somewhat and fans headed to the exits after the midfielder's third for Tottenham.
The break in Everton's winning streak at home will not be a massive worry for David Moyes, but their striker situation are.
The forward and the other striker - the Toffees' pair of recognised centre-forwards - had scored just one league goal combined before the weekend's outing.
And they were failed to contribute to that miserable record on a wet and gloomy night on in Liverpool.
The striker's performance was epitomized when he chose to overhead kick a golden opportunity from near the goal, even with having room and opportunity to reposition for a more conventional shot that would have tested Vicario.
Barry, too, was unable to influence the game after replacing the starter in the 65th minute.
It was not for a shortage of chance. The majority of Everton's attacks came through Grealish and the forward, who tirelessly whipped dangerous balls into the Tottenham penalty area.
What next for these two sides?
Everton: The team travel to the Stadium of Light in the top flight on early November at 8 PM.
Spurs: The London club travel to Newcastle's ground on late October for their fourth-round Carabao Cup match against Newcastle.